Experimental investigation has been performed.
Bioinformatics investigation has been performed

T6SS ID	Type	Organism	Replicon (Accession)	Location	Function

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0181	VC0395_0020/VCA0117 (bEBP/vasH)	T6SS00208	protein	Global regulator	Vibrio cholerae O395	chromosome (NC_009456)	22315..23907 (-)	446006938	T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓)
REG0180	VC0395_RS17530 (TsrA)	T6SS00208 ; T6SS00487	protein	Global regulator	Vibrio cholerae O395	chromosome (NC_009457)	2598392..2598676 (-)	445982516	T6SS Transciption (↑)
REG0182	VC0395_A2109 (rpoN)	T6SS00208	protein	Global regulator	Vibrio cholerae O395	chromosome (NC_009457)	2265078..2266541 (+)	446727517	T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓); hcp promoter (PVCA0017/VC0395_0116) (↓)

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Effector ID	Locus tag (Gene)	Classification	Cognate immunity protein	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Immunity protein ID	Locus tag (Gene)	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Cognate effector

Experimental investigation has been performed.
Bioinformatics investigation has been performed

ID	Locus tag (Gene)	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Response to T6SS attack	Known or putative function

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Accessory protein ID	Locus tag (Gene)	Related T6SS	Type	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Related structure protein	Related effector